24, 2016 1:35 PM ET |By: Douglas W. House , SA News Editor A Phase 3 clinical trial assessing GlaxoSmithKline’s (NYSE: GSK ) asthma med Nucala (mepolizumab) for the treatment of eosinophilic granulomatosis with polyangiitis (EGPA) met both co-primary endpoints and all secondary endpoints. The proportion of patients achieving a duration of remission of at least 24 weeks significantly favored the mepolizumab cohort compared to placebo [n=16/68 (28%); n=2/68 (3%); p<0.001]. The proportion of patients achieving remission at weeks 36 and 48 also significantly favored mepolizumab [n=22/68 (32%); n=2/68 (3%); p<0.001]. The most common serious adverse event in the mepolizumab group was asthma (4%). The most common serious adverse events for placebo were asthma (4%), influenza (3%) and pneumonia (3%). Complete results will be presented at an upcoming medical conference. great siteGlobal regulatory applications are on tap for 2017. Mepolizumab is a humanized IgG monoclonal antibody that binds to interleukin 5 (IL-5), a cytokine that plays a key role in regulating the function of eosinophils , white blood cells that cause airway inflammation. EGPA, also known as Churg-Strauss syndrome , is a rare systemic vasculitic (inflammation of the blood vessel walls) disorder. It affects as many as four million people worldwide.
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